2-pyrrolidinone moiety is not critical for the cognition-enhancing activity of piracetam-like drugs.
نویسندگان
چکیده
Following the indications of previous work, 2-pyrrolidinone moiety of piracetam and piracetam-like compounds has been opened to the corresponding amide derivatives. As found previously in the case of 1,4-diazabicyclo[4.3.0]nonan-9-one compounds, the cognition-enhancing activity of 2-pyrrolidinone compounds is maintained in most cases, suggesting that this moiety is not crucial for activity.
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ورودعنوان ژورنال:
- Farmaco
دوره 58 9 شماره
صفحات -
تاریخ انتشار 2003